22. Sep, 2017

BREAST CANCER AND ESTROGEN METABOLISM

 

We all know that the increase in estrogen hormones or activation of the estrogen receptors are associated with breast cancer. According to extensive research a few factors could contribute to estrogen dominance; external pollutants, stress, inflammation, and most importantly a defect in estrogen metabolism.

There are many pollutants that contribute to estrogen activity, such as xenoestrogens such as DDT, heavy metal toxicity, hormones added in food processing and environmental pollutants.

Stress, especially emotional stress leads to increased cortisol levels and at the same time a decrease in melatonin. A decrease in melatonin results in increasing estrogen and upregulation in estrogen receptors.

Life stressors and the aging process contribute to a decrease in androgen hormones such as DHEA and testosterones which has an impact on the immune system. The immune system creates inflammation which results in increasing enzymes that convert DHEA and testosterones into estrogens.

However, even if we have too many estrogen hormones it doesn’t mean that it can lead to cancer as long as they are effectively metabolized in methylation cycle. The process in itself is extremely complicated and it is very important that these hormones are metabolized the right way. If there is a defect in the methylation process it can create bad estrogen molecules which are highly oxidized and reactive. The defect in the methylation cycle could have a genetic factor but also lack of Vitamins, specially vitamin B6, B12, folic acid, selenium, and iodine.

To summarize my short article, you can avoid estrogen dominance by:

  • Avoiding all pollutants
  • Managing Stress
  • Preventing Inflammation
  • Eating healthy diet
  • Taking the right supplements